![]() Functional organization of the corticofugal system from visual cortex to lateral geniculate nucleus in the cat. A corticothalamic switch: controlling the thalamus with dynamic synapses. The role of the thalamus in the flow of information to the cortex. Cortical connectivity and sensory coding. Using goal-driven deep learning models to understand sensory cortex. First spikes in visual cortex enable perceptual discrimination. Speed of processing in the human visual system. We conclude that cortical feedback sculpts spatial integration in the dLGN, likely via recruitment of neurons in the visTRN. These features make them an ideal candidate for mediating feedback-enhanced surround suppression in the dLGN. We found that visTRN neurons have large RFs, show little surround suppression and exhibit strong feedback-dependent responses to large stimuli. Guided by a network model indicating that widespread inhibitory CT feedback is necessary to reproduce these effects, we targeted the visual sector of the thalamic reticular nucleus (visTRN) for recordings. Here, we show that in awake mice, retinotopically organized cortical feedback sharpens receptive fields (RFs) and increases surround suppression in the dLGN. ![]() How this modulation arises from direct excitatory and indirect inhibitory CT feedback pathways remains enigmatic. En route from the retina to the cortex, visual information passes through the dorsolateral geniculate nucleus (dLGN) of the thalamus, where extensive corticothalamic (CT) feedback has been suggested to modulate spatial processing.
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